Endocrine Abstracts

Introduction: There is only few data on metabolic syndrome occurrence in young patients with childhood-onset GH deficiency (CO-GHD), especially its partial form.Aim: The aim of this study was the assessment of the metabolic syndrome criteria (according to IDF 2007) occurrence in adolescents and young adults with CO-GHD and evaluation of their correlations with the degree of GH/IGF-1 axis function impairment.Subjects and methods: Th...

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

Aims: The aim of our study was to assess the relationships between systemic markers of general inflammation: interleukin 18 (IL-18) and C-reactive protein (CRP) and dehydroepiandrosterone (DHEA) as well as dehydroepiandrosterone sulphate (DHEA-S) serum levels, in addition to the anthropometrical and biochemical indices of metabolic syndrome (MS) in men over the age of 40.Patients and methods: In 271 randomly chosen men aged 40 to 80 years living in Lubus...

A young woman aged 23 years, with non-toxic goiter was treated in our Department. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show very large glands (60 ml), with large nodule in left lobe and smaller one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, with very low uptake i...

Background: Gestational diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. In our study we have endeavoured to assess serum levels of insulin-sensitising omentin and pro-inflammatory thrombospondin-1 (TSP-1) in GDM.Subjects and methods: The study included 20 women with GDM, diagnosed according to the WHO criteria, age 29.7±5.5 (mean±S.D.), BMI...

The commonly expressed multifunctional protein and protooncogene β-catenin displays important functions in cell–cell adhesion and in the Wnt signaling pathway. Transforming activity of the Wnt/β-catenin pathway is thought to be involved in the development of a variety of human cancers and many β-catenin target genes have been shown to play critical functions in tumors. Therefore, the aim of this project was to determine the expression levels and cellular di...

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. It was also exposed to ionizing radiation after the Chernobyl accident in 1986. The aim of the present study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2007. The Regional Cancer Surveillance Program was used to collect data on 834 n...

Cognitive dysfunctions, observed in the course of thyroid diseases (hyper- and hypothyroidism), have – in the recent years – been the subject of interest for many research teams. Even mild disorders of thyroid functionality are associated with hormone concentration changes which affect the general mood and cognitive functions. The efficiency of cognitive functions, which allow the man’s adaptation to environment al conditions, is determined by the activities of ...

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients present signs of hormone excess: virilisation, Cushing’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy and ...

Introduction: The peroxisome proliferator-activated receptors gamma (PPARγ) are nuclear receptors which are detected in normal and pathological tissues. Our earlier study showed the overexpression of PPARγ in human adrenal tumors and pituitary adenomas in comparison to normal glands. The in vitro experiments indicated that ligands of PPARγ inhibit growth of many tumors including pituitary adenomas, thyroid cancers and adrenal carcinomas. However, the data...